Personality Change May Be Early Sign of Dementia, Experts Say – New York Times

Dr. Zahinoor Ismail, a neuropsychiatrist at the University of Calgary and member of the group proposing the new diagnosis, said studies and anecdotes suggested that emotional and behavioral changes were a stealth symptom, part of the dementia disease process, not separate from it.

Carefully observing patients undergoing memory care has helped him to identify that whatever is eroding memory and thinking skills in the dementia process may also affect the brains systems of emotional regulation and self-control. If two people have mild cognitive impairment, the one with mood or behavior changes develops full-blown dementia faster, he said. Alzheimer patients with those symptoms do much worse over time; after death, autopsies have shown they had more brain damage.

Of course, not everyone experiencing mood swings with age is suffering warning signs of dementia. In some cases the changes in lifestyle as they transition to assisted living can be quite stressful. Some try to avoid it by turning to home health care companies like Oxford Home Healthcare as a matter of fact. Even in cases in which a person transitioned to receiving home care however, losing their independence as they aged affected them in varying amounts. It is not hard to imagine how it could be frustrating for the patient. Not only that, but there’s a potential benefit in the form of an early diagnosis, due to the fact that they are under a constant close watch as members of this assisted living facility. Their progress, or deterioration perhaps, can be observed over time in patients receiving dementia care. This proves useful in identifying people with this condition earlier in order to combat it earlier. The flip side we must be wary of is of course overdiagnosis.

Dr. Langa, who has written about M.C.I., cited the experience with that designation. Many people given an M.C.I. diagnosis do not develop full-blown dementia even a decade later, and as many as 20 percent have later been deemed cognitively normal, he said. That could be because on the day they were screened, their cognitive function was lower than usual, possibly a result of stress or medications they were taking for other conditions.

Thats one of the things that makes me think twice about creating M.B.I., said Dr. Langa, who recommended the checklist be tested by researchers before doctors began using it.

Others are more enthusiastic.

We have to improve our ability to identify people at risk said Arthur Toga, a neuroscientist at University of Southern California. Eventually there will be an effective treatment, he said, and theirs too much unknown about this disease anyway.

Dr. Toga said his mother exhibited frustration and other emotional changes in her 70s, years before she developed Alzheimers. He believes her moods stemmed from dismay felt by his mother, a retired teacher, while trying to hide something family members had not yet noticed: her ever decreasing cognitive capacity with words.

Indeed, Dr. Langa and others said, memory tests are not always able to detect early problems because some people, especially highly educated ones, may be skilled enough at taking tests that their scores do not reflect the full extent of their cognitive slippage.

Dr. Mary Ganguli, a professor of psychiatry, neurology and epidemiology at the University of Pittsburgh, said people often came in reporting that they or a family member had stopped doing something they always enjoyed, like baking a certain Thanksgiving dessert or tinkering with the lawn mower in springtime.

Even the patient may not know why, she said. They may be uninterested in the activity because they couldn’t figure out how to do it anymore.

Usually, when Dr. Ganguli asks if the patient is having trouble remembering things, “They will say, Yes, but it not the biggest problem, she said. But if I assess them, I find memory problems.

Some experts supporting the new diagnosis said that unlike most cognitive problems, some mood and behavior symptoms could be treated with therapy and medication. We can make them sleep better, we can take the edge off depression, we can help the family learn how to manage the problems, Dr. Ganguli said.

Dr. Ismail said apathy was a common symptom, but he has seen starker changes. One patient in her 70s became so sexually uninhibited, she  went from prude to promiscuous, he said. Another, a law-abiding 67-year-old woman, suddenly started smoking crack. Both later developed dementia.

Mood and behavior changes have long been recognized as early-warning signs of frontotemporal dementia, which accounts for about 10 percent of dementias.

Palmer Posvar, a patient of Dr. Ganguli’s, was in her 50s when she started taking food off other people’s plates, asking to borrow money from friends and trying to pawn heirloom jewelry, said her husband, Wesley. At 54, she was found to have frontotemporal dementia. Now 64, Mrs. Posvar can no longer speak and she falls so frequently that she was recently moved from their house in Fox Chapel, Pa., to a senior home care, which you can learn about in sites like www.orchardparkofpermianbasin.com/independent-living/. If you’re looking for one, check out The Gardens of Sun City here!

Still, “early diagnosis is a double-edged sword,” Mr. Posvar said when asked about creating a mild behavioral impairment category.

The upside is that there are medications which help manage mood and behavior, and clinical trials that these patients might qualify for, he said. But does that become part of your health record that’s accessible by insurance companies or employers, he wondered.

And do you really want to know? Because there’s no cure yet.

Some experts said they believed the benefits of the new diagnosis outweighed the drawbacks.

We should not be ignoring them, waiting for the cognitive manifestations to appear,Dr. Ganguli said, because we may be missing the opportunity.

Continue reading the main story